Buck Institute – COVID 19 Perspectives Buck Institute – COVID 19 Perspectives

Nevan Krogan, PhD

Director, Quantitative Biosciences Institute at University of California, San Francisco

Senior Director, Gladstone Institute

Adjunct faculty, Buck Institute

Recorded: Wednesday, May 6th

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About

Join Nevan Krogan, live Wednesday, May 6th, as he shares his perspective on how to think about, deal with, and potentially treat the COVID-19 pandemic.

Nevan is the director of the Quantitative Biosciences Institute at UCSF. He is also a senior director at the Gladstone Institutes, faculty at the Helen Diller Family Comprehensive Cancer Center, director at the Thermo Fisher Scientific Proteomics Facility for Disease Target Discovery, and adjunct faculty at the Buck. He received his PhD from the University of Toronto.

Since the outbreak of COVID-19 in China, the Krogan lab has been singularly focused on understanding how SARS-CoV-2—the virus that causes the disease—hijacks the machinery of human cells to replicate itself. The Krogan lab has identified all the human proteins that interact with SARS-CoV-2. Nevan is now spearheading the QBI Coronavirus Research Group, an international collaboration to test 69 potential drugs against the virus.

“I’ve never seen this many scientists bring their diverse expertise together to work on a single problem.”

–Nevan Krogan in conversation with the UCSF News Bureau

Questions

Help shape the upcoming conversation.

In his session, Nevan Krogan will respond to the questions registered attendees sent in through this page, in the live discussion and social media.

  • 4

    votes

    All over the Harvard Model Study is mention of Cross Immunity between the 2 BETA COMMON Coronaviruses. And possibly between those 2 and COVID-19 !
    ” The Cross Immunity that HCoV-OC43 infection induces against HCoV-HKU1 is stronger than the reverse ( 70%)”. …
    “mild (30%) cross-immunity from HCoV-OC43 and HCoV-HKU1 could effectively eliminate the transmission of SARS-CoV-2 for up to three years”
    Could there be Cross Immunity from the Common BETA Coronaviruses ( that cause the Common Cold) to COVID-19?
    I’ll so gladly catch this Cold if it is!!!
    COULD THIS BE A TREATMENT?
    SOURCE: http://www.marininfo.org/Healthcare/COVID-19/covid19.htm

  • 4

    votes

    Could you please describe the relationship between seasonality and the virus? What is it about a particular season that makes the virus more abundant?

  • 3

    votes

    Which of the potential drugs seem most promising? How do you choose the drugs to focus on?

  • 3

    votes

    Will COVID-19 be around every year like the common cold and flu?

  • 2

    votes

    What is your take on Standford’s preliminary results published Friday? Are the studies at UC Berkely and USC consider peer reviews? Thank you.

  • 2

    votes

    How does COVID-19 affect the body differently than past coronaviruses?

  • 2

    votes

    How long does the virus stay on surfaces for?

  • 2

    votes

    I have heard that you can contract the virus up to 3 hours later in a place that someone has coughed or sneezed. Is this true?

  • 2

    votes

    Please clarify whether or not Ibuprofen or dextromethazone should be avoided during the Covid19 era, and explain why this is so. Is Tylenol safe to use? Do beta blockers accelerate Covid19 in the body? Thank you.

  • 2

    votes

    Once COVID has entered the body, how long does it take to show up on a test?

  • 2

    votes

    Are there any studies being done on the use of natural remedies such as supplements botanicals or homeopathy for the treatment and prevention of Covid.

  • 1

    votes

    Is a universal vaccine that could offer protection against all coronaviruses possible?

  • 1

    votes

    Is cordyceps as an mTOR inhibitor of interest to investigators?

  • 1

    votes

    I have heard that the use of vaccines can cause mutations and more virulent strains in what they are trying to prevent. Shouldn’t this be a consideration when looking into vaccine use for this virus?

  • 1

    votes

    Can you say with 100% certainty that Covid-19 did not come from a lab that does gain-of-function research experiments? — How did that polybasic furin cleavage site PRRA get into Covid-19?

  • 1

    votes

    Please address the issue of dextromethorphan concerns that you have observed and also pls address issues about the virus mutating. How soon could we see this?

  • 1

    votes

    :How far out do you predict international travel restrictions will be a concern?

  • 1

    votes

    Please comment on the inadequacy and ineffectiveness of masks that have ‘filters’ discs on them. Most people aren’t aware of their lack of protection.

  • 1

    votes

    Your lab has done interaction maps for different viruses. Is your sense that there are some commonalities among different viruses’ host cofactors? Is there a hope for pan-antivirals?

  • 0

    votes

    Late Feb. I developed an itchy torso rash, dry cough, fatigue & 2 degree temp. (99.1). Feb. 29 added PE-like shortness of breath that lasted 8-10 days. A Quest C-19 antibody test last week was negative. Can I have had the virus yet have tested negative?